Wnt-p53 inhibitor compound 2
更新时间：2024-07-17 16:20:58
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| 常用名 | Wnt-p53 inhibitor compound 2 | CAS号 | 1448427-02-8 |
|---|---|---|---|
| 价格 | ￥需询单/100mg ￥需询单/250mg ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Wnt-p53 inhibitor compound 2 is a novel inhibitor targets both Wnt signaling and ATM/p53, potently inhibits Wnt transcription (IC50=11 nM) and p53 transcription (EC50=1.9 nM); decreases HCT-116 CRC cell viability (IC50=10 nM) and proliferation (IC50=8 nM), decreases DLD-1, SW480 and 10.1 cancer cell viability (IC50=12, 27 and 41 nM) and proliferation (IC50=18,15 and 13 nM); compound 2 potently activates apoptosis of HCT-116, DLD-1 and SW480 cells (EC50=13, 15 and 18 nM) in a p53-dependent manner; inhibits cell migration and invasion in HCT-116 at 20-200 nM, also modulates mitotic stress signaling, leading to both inhibition of Wnt responsiveness and stabilization and activation of p53 to cause cell cycle arrest; induces cell death and inhibits tumor growth in mouse xenografts (20 mg/kg/day, i.p.), without acute cytotoxicity nor toxicity. 物理化学性质： CAS号：1448427-02-8 常用中文名：Wnt-p53 inhibitor compound 2 常用英文名：Wnt-p53 inhibitor compound 2 分子式：C19H21N3O3S 分子量：371.455 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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