Lu AA41178
更新时间：2024-07-17 16:20:39
采购访问：7次
| 常用名 | Lu AA41178 | CAS号 | 908608-34-4 |
|---|---|---|---|
| 价格 | ￥需询单/100mg ￥需询单/250mg ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Lu AA41178 is a potent, pan-selective Kv7.2-7.5 opener with EC50 of 1.5, 0.6 20.5, and 37.0 uM for Kv7.2, Kv7.2/7.3, Kv7.4 and Kv7.5, respectively.Lu AA41178 displays no activity at Kv7.1 channels, has no potentiating impact on currents through GABAA ion channels, and a clean off-target profile against common cardiac ion channels.Lu AA41178 significantly increased the seizure thresholds in mice, demonstrating anticonvulsant efficacy in the maximum electroshock seizure threshold test and PTZ seizure threshold test.Lu AA41178 demonstrated antipsychotic-like activity by reducing amphetamine-induced hyperlocomotion in mice as well as lowering conditioned avoidance responses in rats, significantly reduced immobility in mouse model with antidepressant predictivity. 物理化学性质： CAS号：908608-34-4 常用中文名：Lu AA41178 常用英文名：Lu AA41178 分子式：C17H27N3O2 分子量：305.422 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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