SKLB-03176
更新时间：2026-01-30 17:19:01
采购访问：13次
| 常用名 | SKLB-03176 | CAS号 | 2609675-22-9 |
|---|---|---|---|
| 价格 | ￥需询单/5mg | 纯度 | 98.0% |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： SKLB-03176 (SKLB03176) is a potent, selective, covalent EZH2 inhibitor with IC50 of 47 nM, covalently binds to the SAM pocket of EZH2.SKLB-03176 showed good inhibitory activity against mutations EZH2 Y641F, EZH2 Y641N, and EZH2A677G at 200 nM concentration.SKLB-03176 exhibited weak activity against other targets, such as 5 histone methyltransferases and more than 30 kinases, >50-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1 (IC50=2.45 uM).SKLB-03176 inhibited the activity of a variety of EZH2 mutants and significantly inhibited the expression of H3K27Me3 in cells.SKLB-03176 showed no cytotoxicity to normal cells. 物理化学性质： CAS号：2609675-22-9 常用中文名：SKLB-03176 常用英文名：SKLB-03176 分子式：C29H34N6O3 分子量：514.63 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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