Piboserod Hydrochloride

更新时间：2024-07-17 15:20:23 采购访问：12次

常用名	盐酸Piboserod	CAS号	178273-87-5
价格	￥需询单/100mg ￥需询单/250mg ￥需询单/1g	纯度	98.0%
备货期	10天	库存	3

产品详情（用途，包装等）用途： Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist.IC50 value:Target: 5-HT4 antagonistin vitro: Piboserod did not modify the basal contractions but concentration-dependently antagonized the ability of 5-HT to enhance bladder strip contractions to EFS. In presence of 1 and 100 nM of piboserod, the maximal 5-HT-induced potentiations were reduced to 45.0+/-7.9 and 38.7+/-8.7%, respectively [1].in vivo: Piboserod significantly increased LVEF by 1.7% vs. placebo (CI 0.3, 3.2, P = 0.020), primarily through reduced end-systolic volume from 165 to 158 mL (P = 0.060). There was a trend for greater increase in LVEF (2.7%, CI -1.1, 6.6, P = 0.15) in a small subset of patients not on chronic beta-blocker therapy. There was no significant effect on neurohormones, quality of life, or exercise tolerance. Patients on piboserod reported more adverse events, but numbers were too small to identify specific safety issues [2]. Pretreatment with potent 5-HT4 ligands dose-dependently reduced striatal SB207145 concentration and the effective dose to achieve 50% receptor occupancy (ED50 ) values were 4.8, 2.0, 7.4, 9.9, 3.8 and 0.02 mg/kg for GR113808, piboserod, prucalopride, RS67333, TD8954 and PF04995274, respectively [3]. 物理化学性质： CAS号：178273-87-5 常用中文名：盐酸Piboserod 常用英文名：Piboserod (hydrochloride) 分子式：C22H32ClN3O2 分子量：405.96100 密度：N/A 沸点：570.3ºC at 760 mmHg 熔点：N/A 闪点：298.7ºC 储存条件：2-8℃

DC Chemicals Limited

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上海化源生化科技有限公司
上海市上海市普陀区
产品名：Piboserod hydrochloride
价格：
纯度：98.0%
备货期：10天
联系人：徐经理

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盐酸Piboserod生产厂家

参考价格：$156/10mg

2024-07-15

Piboserod hydrochloride
价格：需询单

查看所有价格，请点击盐酸Piboserod价格