常用名 | I-138 | CAS号 | 2098211-50-6 |
---|---|---|---|
价格 | ¥需询单/100mg ¥需询单/250mg ¥需询单/1g ¥220.0/10ml | 纯度 | 98.0% |
备货期 | 10天 | 库存 | 3 |
产品详情(用途,包装等)
用途: I-138 is an orally active compound structurally related to ML323 (HY-17543). I-138 and ML-323 are potent reversible inhibitors of USP1-UAF1. I-138 displays synergistic binding with ubiquitin and mutual exclusive binding with ML323. I-138 induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells. I-138 ablates USP1 autocleavage in cells[1]. 物理化学性质: CAS号:2098211-50-6 常用中文名:I-138 常用英文名:I-138 分子式:C26H23F3N6O 分子量:492.50 密度:N/A 沸点:N/A 熔点:N/A 闪点:N/A |