| 常用名 | SMER18 | CAS号 | 944153-47-3 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential. 物理化学性质: CAS号:944153-47-3 常用中文名:SMER18 常用英文名:SMER18 分子式:C16H14ClNO2 分子量:287.741 密度:1.3±0.1 g/cm3 沸点:458.7±45.0 °C at 760 mmHg 熔点:N/A 闪点:231.2±28.7 °C 储存条件:2-8℃ |