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((((S)-1-(4-溴苯基)乙基)氨基)(2,3-二氧代-1,2,3,4-四氢喹喔啉-5-基)甲基)膦酸

更新时间:2024-07-15 12:35:22 采购访问:11次

常用名 PEAQX CAS号 459836-30-7
价格 纯度 98.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).IC50 value: 270 nM(hNMDA A1/A2) [1]Target: NR2A antagonistin vitro: PEAQX has a high binding affinity for NMDA receptors (IC50=8 nM), and a functional preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over 1A/2B receptors (IC50=29,600 nM) [1].in vivo: PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23 mg/kg in the MES test [1]. Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10 mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40 mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10 mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20 mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to PCP challenge on PN28-PN35 [2].
物理化学性质:
CAS号:459836-30-7
常用中文名:PEAQX
常用英文名:NVP-AAM077
分子式:C17H17BrN3O5P
分子量:454.212
密度:1.6±0.1 g/cm3
沸点:N/A
熔点:N/A
闪点:N/A
储存条件:2-8℃

供应商信息

上海念兴实业有限公司 认证供应商

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参考价格:$144/5mg
其他供应商价格:
2024-07-15 ((((S)-1-(4-溴苯基)乙基)氨基)(2,3-二氧代-1,2,3,4-四氢喹喔啉-5-基)甲基)膦酸
价格:需询单
2022-11-29 NVP-AAM077
价格:¥需询单
2021-02-06 PEAQX
价格:¥1429.0
2023-09-13 NVP-AAM077
价格:¥需询单
2022-05-12 PEAQX
价格:$361.0

查看所有价格,请点击PEAQX价格