K-7174
更新时间：2024-07-15 12:33:14
采购访问：18次
| 常用名 | K-7174二盐酸盐 | CAS号 | 191089-60-8 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.IC50 value:Target: GATA-specific inhibitorin vitro: K-7174 inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either tumor necrosis factor alpha or interleukin-1beta, without affecting the induction of intercellular adhesion molecule-1 or E-selectin. K-7174 had no effect on the stability of VCAM-1 mRNA.K-7174 did not influence the binding to any of the following binding motifs: octamer binding protein, AP-1, SP-1, ets, NFkappaB, or interferon regulatory factor [1]. Addition of 10 microM K-7174 rescued these inhibitions of Epo protein production and promoter activity induced by IL-1beta, TNF-alpha, or L-NMMA, respectively [2]. K-7174 had the potential to induce endoplasmic reticulum (ER) stress evidenced by induction of GRP78 and CHOP.Other inducers of ER stress completely reproduced the effects of K-7174 including suppression of lipid accumulation, blockade of induction of adiponection and PPARgamma and maintenance of MCP-1 expression [3].in vivo: K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib [4]. 物理化学性质： CAS号：191089-60-8 常用中文名：K-7174二盐酸盐 常用英文名：K-7174 (dihydrochloride) 分子式：C33H50Cl2N2O6 分子量：641.67 密度：1.1±0.1 g/cm3 沸点：689.9±55.0 °C at 760 mmHg 熔点：N/A 闪点：171.2±28.7 °C 储存条件：2-8℃ |
上海念兴实业有限公司
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- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：K-7174
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：化源网
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：K-7174 dihydrochloride
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：K-7174
- 价格： ￥1089.0/5mg ￥3589.0/25mg ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：K-7174 dihydrochloride
- 价格： ￥6500.9/50mg ￥1650.9/10mg ￥1100.9/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$169/10mM*1mLinWater