3PO
更新时间：2024-07-15 12:33:08
采购访问：15次
| 常用名 | 3PO | CAS号 | 18550-98-6 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： 3PO is a novel small-molecule inhibitor of the PFKFB3 isozyme, 3PO markedly attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50, 1.4-24 μM) IC50 valueTarget: PFKFB3 isozymein vitro: 3PO inhibits recombinant PFKFB3 activity, suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH. 3PO markedly attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50, 1.4-24 μM) and is selectively cytostatic to ras-transformed human bronchial epithelial cells relative to normal human bronchial epithelial cells. The PFKFB3+/- fibroblasts were more sensitive to compound 3PO treatment (IC50, 26 μM) compared with the wild-type PFKFB3+/+transformed cells (IC50, 49 μM).3PO Causes G2-M Phase Arrest, Which Is Preceded by Decreased Fru-2,6-BP and Glucose Uptake. 3PO slows growth through inhibition of PFK-2 activity, then ectopic expression of the PFKFB3 isozyme may thwart the cytostatic activity of 3PO. [1] 3PO inhibits the glycolytic regulator PFKFB3 in endothelial cells (ECs). 3PO decreases glycolysis in ECs and impairs vessel sprouting. 3PO also suppresses vascular hyperbranching induced by inhibition of Notch or VEGF receptor 1 (VEGFR1) and amplified the antiangiogenic effect of VEGF blockade. [2]in vivo: Compound 3PO treatment significantly reduced Fru-2,6-BP in tumor xenografts compared with vehicle control (vehicle: 13.1 ± 1.9 pmol/mg, 3PO: 8.5 ± 1.7 pmol/mg). [1] 3PO also impairs (pathological) angiogenesis. [2] 物理化学性质： CAS号：18550-98-6 常用中文名：3PO 常用英文名：3PO 分子式：C13H10N2O 分子量：210.231 密度：1.2±0.1 g/cm3 沸点：387.8±42.0 °C at 760 mmHg 熔点：N/A 闪点：191.3±34.3 °C 储存条件：-20℃ |
上海念兴实业有限公司
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商品数：403768件
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地址：2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区： 上海市 上海市 普陀区
联系人：小陈
联系人电话：0086-021-52280163
邮件：sales@echemcloud.com
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：3PO
- 价格： ￥1412.9/25mg ￥2471.9/50mg ￥562.9/5mg ￥4325.9/100mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：(E)-3-(吡啶-3-基)-1-(吡啶-4-基)丙-2-烯-1-酮
- 价格： ￥需询单/1g ￥需询单/250mg ￥需询单/5g
- 纯度：99.0%
- 备货期：需询单
- 联系人：王汐瑶
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：3PO
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$66/10mM*1mLinDMSO