Rimonabant
更新时间：2024-07-15 12:32:46
采购访问：18次
| 常用名 | 利莫纳班 | CAS号 | 168273-06-1 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Rimonabant(SR141716) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.8 nM.IC50 Value: 1.8 nM(Ki)Target: CB1 Receptorin vitro: Rimonabant dose-dependently reduces ACAT activity in Raw264.7macrophages with IC50 of 2.9 μM and isolated peritoneal macrophages. Rimonabant inhibits ACATactivity in intact CHO-ACAT1 and CHO-ACAT2 cells and in cell-free assays with approximately equal efficiency with IC50 of 1.5 μM and 2.2 μM for CHO-ACAT1 and CHO-ACAT2, respectively. Consistent with ACAT inhibition, Rimonabant treatment blocks ACAT dependent processes in macrophages, oxysterol-induced apoptosis and acetylated-LDL induced foam cell formation. Rimonabant antagonizes the inhibitory effects of cannabinoid receptor agonists on both mouse vas deferens contractions and adenylyl cyclase activity in rat brain membranes in a concentration-dependent manner.in vivo: Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES (Regulated upon Activation, Normal T cell Expressed, and Secreted) and MCP-1 (monocyte chemotactic protein-1) serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant. Platelets from obese rats are more sensitive to thrombin-induced aggregation and adhesion to fibrinogen, which are both attenuated by Rimonabant therapy. 物理化学性质： CAS号：168273-06-1 常用中文名：利莫纳班 常用英文名：Rimonabant 分子式：C22H21Cl3N4O 分子量：463.787 密度：1.4±0.1 g/cm3 沸点：627.6ºC at 760 mmHg 熔点：230-240ºC 闪点：333.3ºC 储存条件：2~8°C |
上海念兴实业有限公司
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- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：Rimonabant
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：化源
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Rimonabant(SR141716)
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺
- 价格： ￥需询单/100mg ￥需询单/1g ￥需询单/250mg ￥需询单/25g
- 纯度：99.0%
- 备货期：需询单
- 联系人：王汐瑶
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Rimonabant
- 价格： ￥356.9/100mg ￥54.9/10mg ￥441.9/1ml ￥223.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：￥437/10mg