坦度螺酮柠檬酸盐
更新时间：2024-07-15 12:30:11
采购访问：23次
| 常用名 | 枸橼酸坦度螺酮 | CAS号 | 112457-95-1 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM). IC50 Value: 27±5 nM(Ki) [1]Target: 5-HT1Ain vitro: Tandospirone is most potent at the 5-HT1A receptor, displaying a Ki value of 27 +/- 5 nM. The agent is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, alpha 1-adrenergic, alpha 2-adrenergic, and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM). Tandospirone is essentially inactive at 5-HT1B receptors; 5-HT uptake sites; beta-adrenergic, muscarinic cholinergic, and benzodiazepine receptors [1]. 3H-SM-3997 bound rapidly, reversibly and in a saturable manner with high affinity to rat brain hippocampal membranes (Kd = 9.4 nM, Bmax = 213 fmol/mg protein) [2]. in vivo: Chronic treatment with tandospirone, at 0.2 and 1.0mg/kg/day, but not 2.0mg/kg/day, attenuated footshock stress-induced eLAC elevation in the mPFC [3]. Rats were acutely administered tandospirone (0, 0.1, and 1 mg/kg, i.p.). Tandospirone decreased the number of premature responses, an index of impulsive action, in a dose-dependent manner [4].Toxicity: It is not believed to be addictive but it is known to produce mild withdrawal effects (e.g. anorexia) after abrupt discontinuation. 物理化学性质： CAS号：112457-95-1 常用中文名：枸橼酸坦度螺酮 常用英文名：Tandospirone Citrate 分子式：C27H37N5O9 分子量：575.611 密度：N/A 沸点：613.9ºC at 760 mmHg 熔点：N/A 闪点：325.1ºC 储存条件：2-8℃ |
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- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：坦度螺酮柠檬酸盐
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Tandospirone citrate
- 价格： ￥6380.9/100mg ￥600.9/5mg ￥3999.9/50mg ￥884.9/10mg
- 纯度：99.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$96/5mg