| 常用名 | NSC 145366 | CAS号 | 1052515-37-3 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells. 物理化学性质: CAS号:1052515-37-3 常用中文名:NSC 145366 常用英文名:NSC 145366 分子式:C37H63ClN2O4 分子量:635.371 密度:N/A 沸点:N/A 熔点:N/A 闪点:N/A |