Z-ILE-LEU-ALDEHYDE
更新时间：2024-05-30 16:54:21
| 常用名 | Z-岛-亮氨酸醛 | CAS号 | 161710-10-7 |
|---|---|---|---|
| 价格 | $需询单/1mg $需询单/100kg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Z-Ile-Leu-aldehyde(Z-IL-CHO; GSI-XII) is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.IC50 value:Target: gamma-Secretase inhibitorin vitro: GSI-XII induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity. GSI XII impairs murine osteoclast differentiation of receptor activator of NF-κB ligand (RANKL)-stimulated RAW264.7 cells in vitro [1]. Notch-signaling inhibition in HRS cells by the γ-secretase inhibitor (GSI) XII results in decreased alternative p52/RelB NF-κB signaling, interfering with processing of the NF-κB2 gene product p100 into its active form p52 [2]. GSI treatment induced morphologic erythroid differentiation and promoted hemoglobin production. GSI treatment suppressed short-term growth and colony formation, while treatment with GSI-XXI promoted the growth of AA cells [3].in vivo: In the murine MOPC315.BM myeloma model GSI XII has potent anti-MM activity and reduces osteolytic lesions as evidenced by diminished myeloma-specific monoclonal immunoglobulin (Ig)-A serum levels and quantitative assessment of bone structure changes via high-resolution microcomputed tomography scans [1]. 物理化学性质： CAS号：161710-10-7 常用中文名：Z-岛-亮氨酸醛 常用英文名：Z-Ile-Leu-aldehyde 分子式：C20H30N2O4 分子量：362.46300 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Z-Ile-Leu-aldehyde
- 价格： ￥5000.9/10mg ￥2333.9/2mg ￥1600.9/1mg ￥3500.9/5mg
- 纯度：96.0%
- 备货期：10天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：Z-ILE-LEU-ALDEHYDE
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
查看所有供应商和价格请点击：
参考价格：$462/10mM*1mLinDMSO