| 常用名 | Sivelestat sodium tetrahydrate | CAS号 | 201677-61-4 |
|---|---|---|---|
| 价格 | ¥需询单/1g | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.IC50 value: 44 nM [1]Target: neutrophil elastaseONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2]. 物理化学性质: CAS号:201677-61-4 常用中文名:Sivelestat sodium tetrahydrate 常用英文名:Sivelestat Sodium tetrahydrate 分子式:C20H29N2NaO11S 分子量:528.506 密度:N/A 沸点:N/A 熔点:N/A 闪点:N/A 储存条件:-20℃ |