MF63
更新时间：2025-08-29 11:26:56
| 常用名 | 2-(9-氯-1H-菲酚[9,10-d]咪唑-2-基)-1,3-苯二甲腈 | CAS号 | 892549-43-8 |
|---|---|---|---|
| 价格 | ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. IC50 value: 0.9 nM ( pig mPGES-1); 1.3 nM (human mPGES-1)Target: mPGES-1MF63 potently inhibited the human mPGES-1 enzyme with a high degree (>1000-fold) of selectivity over other prostanoid synthases. In rodent species, MF63 strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme. When tested in the guinea pig and a knock-in (KI) mouse expressing human mPGES-1, the compound selectively suppressed the synthesis of PGE(2), but not other prostaglandins inhibitable by nonsteroidal anti-inflammatory drugs (NSAIDs), yet retained NSAID-like efficacy at inhibiting lipopolysaccharide-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. 物理化学性质： CAS号：892549-43-8 常用中文名：2-(9-氯-1H-菲酚[9,10-d]咪唑-2-基)-1,3-苯二甲腈 常用英文名：MF63 分子式：C23H11ClN4 分子量：378.81300 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：MF63
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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2-(9-氯-1H-菲酚[9,10-d]咪唑-2-基)-1,3-苯二甲腈生产厂家
参考价格：$73/10mM*1mLinDMSO