| 常用名 | HLCL-61 HCL | CAS号 | 1158279-20-9 |
|---|---|---|---|
| 价格 | ¥需询单/1g ¥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情(用途,包装等)
用途: HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of PRMT5. Target: PRMT5in vitro: HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also resulted in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.[1] 物理化学性质: CAS号:1158279-20-9 常用中文名:HLCL-61 HCL 常用英文名:HLCL-61 (hydrochloride) 分子式:C23H25ClN2O 分子量:380.910 密度:N/A 沸点:N/A 熔点:N/A 闪点:N/A 储存条件:-20℃ |