SW-033291
更新时间：2024-01-11 17:14:45
| 常用名 | SW033291 | CAS号 | 459147-39-8 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.IC50 value: 0.1 nM(Ki) [1]Target: 15-PGDHin vitro: SW033291 inhibition of 15-PGDH was noncompetitive versus PGE2 over concentrations up to 40 μM PGE2. SW033291 also demonstrated selective high-affinity interaction with 15-PGDH in thermal denaturation assays. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with 50% of maximal stimulation (EC50) at ~75 nM [1].in vivo: mice injected with SW033291 closely phenocopied 15-PGDH knockout mice, with 10 mg per kg of weight (mg/kg) SW033291 inducing a twofold increase in PGE2 levels in bone marrow, colon, lung, and liver. Mice injected with SW033291 at 20 mg/kg daily for 7 days showed equivalent daily weights and activity as mice injected with vehicle-control and showed no adverse changes in blood counts or serum chemistry [1]. 物理化学性质： CAS号：459147-39-8 常用中文名：SW033291 常用英文名：SW 033291 分子式：C21H20N2OS3 分子量：412.591 密度：1.4±0.1 g/cm3 沸点：670.1±55.0 °C at 760 mmHg 熔点：N/A 闪点：359.0±31.5 °C 储存条件：-20℃ |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：SW033291
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：SW 033291
- 价格： ￥6581.9/100mg ￥1235.9/10mg ￥11515.9/250mg ￥2502.9/25mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$110/10mM*1mLinDMSO