FK3311
更新时间：2024-09-10 10:30:03
| 常用名 | N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺 | CAS号 | 116686-15-8 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： FK 3311 is a selective inhibitor of COX-2; antiinflammatory agent.IC50 Value: 1.6 uM [1]Target: COX-2Cyclooxygenase (COX) is an intracellular enzyme that converts arachidonic acid into prostaglandin (PG)G2 and PGH2.in vitro: The racemic mixtures and the (R)- and (S)-isomers of the 2 metabolites were inactive in the PGE2 test. IC50 values were more than 100 uM for (2 and 5), compared to 1.6 uM for FK-3311. Antiinflammatory activity was assessed by inhibition of adjuvant-induced arthritis, and analgesic activity was determined in the acetic acid-induced writhing assay. Following p.o. administration of 10 mg/kg, racemic (2) and its optical isomers showed activity comparable to FK-3311 (76% inhibition) in the adjuvant arthritis test, whereas racemic (5) showed very weak activity, and (R)- and (S)-(5) were not tested. With regard to analgesic effects, FK-3311 and racemic (2) showed 81 and 62% inhibitions, respectively, at a dose of 100 mg/kg p.o. The (R)- and (S)-isomers of (2) and racemic (5) all showed 46% inhibition of writhing syndrome. (R)- and (S)-(5) were less active showing 16 and 20% inhibitions, respectively[1].in vivo: L-PVR, CO, PaO(2), and WDR were significantly (P 物理化学性质： CAS号：116686-15-8 常用中文名：N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺 常用英文名：FK 3311 分子式：C15H13F2NO4S 分子量：341.330 密度：1.4±0.1 g/cm3 沸点：431.3±55.0 °C at 760 mmHg 熔点：N/A 闪点：214.6±31.5 °C 储存条件：2-8℃ |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：FK3311
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：FK 3311
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：FK 3311
- 价格： ￥597.9/5mg ￥791.9/1ml ￥3398.9/100mg ￥889.9/10mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺生产厂家
参考价格：$185/10mM*1mLinDMSO