PHA-665752
更新时间：2023-09-13 09:55:04
| 常用名 | PHA-665752 | CAS号 | 477575-56-7 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM, >50-fold selectivity for c-Met than RTKs or STKs.IC50 value: 9 nMTarget: c-Metin vitro: PHA-665752 significantly inhibits c-Met kinase activity with Ki of 4 nM, and exhibits >50-fold selectivity for c-Met compared with various tyrosine and serine-threonine kinases. PHA-665752 potently inhibits the HGF-stimulated c-Met autophosphorylation with IC50 of 25-50 nM. PHA-665752 also significantly blocks HGF- and c-Met-dependent functions such as cell motility and cell proliferation with IC50 of 40-50 nM and 18-42 nM, respectively. In addition, PHA-665752 potently inhibits HGF-stimulated or constitutive phosphorylation of mediators of downstream of c-Met such as Gab-1, ERK, Akt, STAT3, PLC-γ, and FAK in multiple tumor cell lines [1]. PHA-665752 inhibits cell growth in TPR-MET-transformed BaF3 cells with IC50 of 85%, due to decreasing the production of vascular endothelial growth factor and increasing the production of the angiogenesis inhibitor thrombospondin-1 [3]. 物理化学性质： CAS号：477575-56-7 常用中文名：PHA-665752 常用英文名：PHA-665752 分子式：C32H34Cl2N4O4S 分子量：641.608 密度：1.4±0.1 g/cm3 沸点：890.2±65.0 °C at 760 mmHg 熔点：N/A 闪点：492.2±34.3 °C 储存条件：Store at +4°C |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：(R,Z)-5-((2,6-二氯苄基)磺酰基)-3-((3,5-二甲基-4-(2-(吡咯烷-1-基甲基)吡咯烷-1-羰基)-1H-吡咯-2-基)亚甲基)二氢吲哚-2-酮
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：化源
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：PHA-665752
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：PHA-665752
- 价格： ￥3289.0/50mg ￥5689.0/100mg ￥789.0/10mg ￥889.0/10g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：PHA-665752
- 价格： ￥498.9/5mg ￥1355.9/1ml ￥797.9/10mg ￥2766.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$108/10mM*1mLinDMSO