| 常用名 | AOH1996 | CAS号 | 2089314-64-5 |
|---|---|---|---|
| 价格 | ¥需询单/5g ¥需询单/10g ¥需询单/25g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: AOH1996 is an orally active ligand of replisome component PCNA (Proliferating cell nuclear antigen), targeting to transcription-replication conflict (TRC). AOH1996 stabilizes the interaction of PCNA and RNA polymerase II, causing proteasome-dependent degradation of rpb1 and lethal DNA damages. AOH1996 also interferes the interaction of PCNA and its binding proteins, leading to DNA replication stress and inducing apoptosis. AOH1996 exerts synergistic effect with DNA damage agents, to inhibit tumor cells[1][2]. 物理化学性质: CAS号:2089314-64-5 常用中文名:AOH1996 常用英文名:AOH1996 分子式:C26H22N2O4 分子量:426.46 密度:1.269±0.06 g/cm3(Predicted) 沸点:703.9±50.0 °C(Predicted) 熔点:N/A 闪点:N/A |