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马来酸氟伏沙明

更新时间:2024-10-18 22:55:57

常用名 马来酸氟伏沙明 CAS号 61718-82-9
价格 ¥需询单/1kg 纯度 99.0%
备货期 需询单 库存 现货
 产品详情(用途,包装等)
用途:
Fluvoxamine maleate is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.Target: SSRIsFluvoxamine (maleate) is the maleate salt form of fluvoxamine, which is effective in inhibiting 5-HT uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine [1]. fluvoxamine appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted [2]. Fluvoxamine was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement [3].Clinical indications: Depression; Obsessive compulsive disorder; Social phobia " FDA Approved Date: December 5, 1994Toxicity: Anorexia, Constipation, Dry mouth, Headache, Nausea, Nervousness, Skin rash, Sleep problems, Somnolence, Liver toxicity, Mania, Increase urination, Seizures, Sweating increase, Tremors, or Tourette's syndrome.
物理化学性质:
CAS号:61718-82-9
常用中文名:马来酸氟伏沙明
常用英文名:Fluvoxamine maleat
分子式:C19H25F3N2O6
分子量:434.407
密度:N/A
沸点:370.6ºC at 760 mmHg
熔点:120-121.5ºC
闪点:177.9ºC
储存条件:2-8°C

供应商信息

北京东亚信德药物研究有限公司

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东亚信德药物研究有限公司是以新药研发和API中间体贸易为核心的创新型技术企业,致力于新药技术研究及合同服务。公司拥有从事新药研发、工业化生产、API贸易的专业队伍和标准化实验室,核心业务涵盖化学药物研发、成果转让与合作、API中间体生产及贸易、临床研究服务、进口注册服务等领域。
药物研究中心配置可以满足从小试研究到中试生产优化的技术开发要求。
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制剂研究中心以确保工艺的工业转化为重点,所有设备均按工业化的设备要求配置:冷冻干燥机(原位曲线冻干)、高速压片机、三维混合颗粒机、摇摆式制粒机、高效包衣机、全自动灭菌器、安瓿熔封机等制剂生产设备。实现从实验室工艺至工业化工艺的无缝衔接。
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参考价格:$66/10mM*1mLinDMSO
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