GDC0214
更新时间：2022-06-28 15:29:31
| 常用名 | iJak-381 | CAS号 | 1831144-46-7 |
|---|---|---|---|
| 价格 | ￥需询单/10mg ￥需询单/1g ￥需询单/1kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： iJak-381 (iJak381) is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2; suppresses STAT 6 activation by IL-1, suppresses ovalbumin-induced lung inflammation in both murine and guinea pig asthma models and improved allergen-induced airway hyperresponsiveness in mice; In a model driven by human allergens, iJak-381 had a more potent suppressive effect on neutrophil-driven inflammation compared to systemic corticosteroid administration, reduces lung pathology without affecting systemic Jak1 activity in rodents. 物理化学性质： CAS号：1831144-46-7 常用中文名：iJak-381 常用英文名：iJak-381 分子式：C28H28ClF2N9O3 分子量：612.039 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |