SD-36

更新时间：2024-07-17 15:06:24 采购访问：25次

常用名	SD 36	CAS号	2429877-44-9
价格	$需询单/1g	纯度	98.0%
备货期	3天	库存	3
产品网页	https://www.dcchemicals.com/product_show-sd-36.html

产品详情（用途，包装等） SD-36 (STAT3 degrader SD-36) is a potent, selective STAT3 degrader (PROTAC), potently induces the degradation of STAT3 protein in vitro and in vivo.SD-36 is designed using an analogue of CRBN ligand lenalidomide and the STAT3 inhibitor SI-109, binds to recombinant STAT3 protein with Ki of 11 nM.SD-36 (250 nM) depleted >90% of STAT3 protein in MOLM-16 cells after 4 hr treatment and >50% of STAT3 protein in DEL, KI-JK and SU-DHL-1 cells after 7 hr treatment, also efficiently degraded STAT3 protein in murine cells.SD-36 displays extremely high cellular selectivity for degradation of STAT3 over other STATs.SD-36 effectively degrades both wild-type and mutated STAT3 proteins in cells, effectively degrades mutated STAT3 (D661Y, K658R mutant), also effectively degrades CRISPR-mutated homozygous Y705F mutant STAT3 protein in DLD-1/STAT3Y705F/Y705F cells.SD-36 displayed strong growth-inhibitory activities in a subset of leukemia and lymphoma cell lines (MOLM-16 cell line IC50, 35 nM), 100-fold more potent than SI-109.SD-36 (i.v. 25 mg/kg) effectively and selectively depletes STAT3 protein, achieves complete and long-lasting tumor regression in in mouse xenograft tumors.

DC Chemicals Limited

认证状态：已认证供应商
商品数：34961件
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地址：浦东新区金豫路100号
地区：上海市上海市浦东新区
联系人：Tony Cao
联系人电话：13564518121
邮件：sales@dcchemicals.com
网址：http://www.dcchemicals.com
主要市场：
年贸易额：>1000万
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D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.

D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.

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上海化源生化科技有限公司
上海市上海市普陀区
产品名：SD-36
价格：
纯度：98.0%
备货期：10天
联系人：徐经理

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：SD-36
价格：￥27000.9/5mg
纯度：98.0%
备货期：10天
联系人：阿拉丁

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SD 36生产厂家

2024-07-15	SD-36 价格：需询单
2025-02-05	SD-36 价格：￥27000.9

查看所有价格，请点击SD 36价格