Rv1625c agonist V-59

更新时间：2024-07-17 15:06:27 采购访问：14次

常用名	Rv1625c agonist V-59	CAS号	958588-17-5
价格	$850.0/100mg $1300.0/250mg $2600.0/1g	纯度	98.0%
备货期	3天	库存	3
产品网页	https://www.dcchemicals.com/product_show-rv1625cagonistv-59.html

产品详情（用途，包装等） Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium.

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