常用名 | YQ128 | CAS号 | 2454246-18-3 |
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价格 | ¥450.0/100mg ¥750.0/250mg ¥1350.0/1g | 纯度 | 98.0% |
备货期 | 1天 | 库存 | 3 |
产品网页 | https://www.dcchemicals.com/product_show-DC60119.html |
产品详情(用途,包装等)
YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 ± 0.01 μM. Further studies from in vitro and in vivo models confirmed its selective inhibition on the NLRP3 inflammasome and its brain penetration. Furthermore, pharmacokinetic studies in rats at 20 mg/kg indicated extensive systemic clearance and tissue distribution, leading to a half-life of 6.6 h. |