Chikusetsu saponin IV a
更新时间：2023-01-31 19:30:25
采购访问：27次
| 常用名 | 竹节参皂苷IVa | CAS号 | 51415-02-2 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Chikusetsusaponin IVa a major active ingredient of triterpenoid saponins, exerts antithrombotic effects, including minor hemorrhagic events. This appears to be important for the development of new therapeutic agents. a novel AMPK activator that is capable of bypassing defective insulin signalling and could be useful for the treatment of T2DM or other metabolic disorders.IC50 Value: 199.4 ± 9.1 μM (inhibiting thrombin-induced fibrinogen clotting) Target: In vitro: Using biochemical and pharmacological methods, it proves that chikusetsusaponin IVa prolongs the recalcification time, prothrombin time, activated partial thromboplastin time, and thrombin time of normal human plasma in a dose-dependent manner; inhibits the amidolytic activity of thrombin and factor Xa upon synthetic substrates S2238 and S2222; inhibits thrombin-induced fibrinogen clotting (50% inhibition concentration, 199.4 ± 9.1 μM); inhibits thrombin- and collagen-induced platelet aggregation. Chikusetsusaponin IVa can also preferentially inhibits thrombin in a competitive manner (K(i)=219.6 μM) [1]. Chikusetsusaponin IVa suppresses the production of iNOS, COX-2, IL-1β, IL-6, and TNF-α in LPS-stimulated THP-1 cells likely by inhibiting NF-κB activation and ERK, JNK, and p38 signal pathway phosphorylation [2].In vivo: Studies were performed on type 2 diabetic mellitus (T2DM) rats given CHS for 28 days to test the antihyperglycemic activity. Oral administration of CHS dose-dependently increased the level of serum insulin and decreased the rise in blood glucose level [3]. 物理化学性质： CAS号：51415-02-2 常用中文名：竹节参皂苷IVa 常用英文名：Chikusetsusaponin IVa 分子式：C42H66O14 分子量：794.965 密度：1.4±0.1 g/cm3 沸点：873.3±65.0 °C at 760 mmHg 熔点：218-220 ºC (methanol , water ) 闪点：255.6±27.8 °C |
达阳化工（杭州）有限公司
认证状态：已认证供应商
商品数：50181件
电话：+86571-88938639
地址：浙江省杭州市西湖区文三路259号2栋9楼
地区： 浙江省 杭州市 西湖区
联系人：王小姐
联系人电话：+86-571-8893-8639
邮件：enquiry@dycnchem.com
网址：http://www.dycnchem.com
主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 云南西力生物技术股份有限公司
- 云南省 昆明市 盘龙区
- 产品名：竹节参皂苷IVa
- 价格： ￥需询单/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：郑雪平
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：竹节参皂苷IVA
- 价格： ￥720.9/10mg ￥112.9/1mg ￥1441.9/25mg ￥463.9/5mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 四川恒诚致远生物科技有限公司
- 四川省 成都市 温江区
- 产品名：竹节参皂苷Ⅳa
- 价格： ￥需询单/5mg ￥需询单/20mg ￥需询单/100mg ￥需询单/1g
- 纯度：98.0%
- 备货期：需询单
- 联系人：张半夏
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参考价格：$231/10mM*1mLinDMSO