((R)-1-((2S,3R)-3-HYDROXY-2-(6-PHENYLPICOLINAMIDO)BUTANAMIDO)-3-METHYLBUTYL)BORONIC ACID
更新时间：2022-03-08 17:15:06
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| 常用名 | Delanzomib | CAS号 | 847499-27-8 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Delanzomib(CEP-18770) is a novel orally-active inhibitor of the chymotrypsin-like activity of the proteasome that down-modulates the nuclear factor-kappaB (NF-kappaB) activity.IC50 Value: 3.8 nM [1]Target: proteasomein vitro: CEP-18770 and bortezomib showed comparable potency against chymotrypsin-like proteasome activity, cellular inhibitory activity (IC50) values of 3.8 (± 1.0) nM and 3.8 (± 0.4) nM, respectively, CEP-18770 had a 2- to 11-fold lower cytotoxic potency compared with bortezomib against solid tumor cell lines, comparable potency against 2 hematologic tumor cell lines, and a similar spectrum of antiproliferative activity with IC50 values for both compounds of less than 35 nM [1].in vivo: in MM xenograft models, the addition of CEP-18770 IV to melphalan completely prevented the growth of both melphalan-sensitive and melphalan-resistant tumours. The combination of CEP-18770 IV and bortezomib induced complete regression of bortezomib-sensitive tumours and markedly delayed progression of bortezomib-resistant tumours compared to treatment with either agent alone [2]. Age matched MRL/lpr or NZBWF1 mice with established SLE or LN, respectively, were treated with delanzomib either 3 mg/kg once or twice weekly intravenously or orally at 10 mg/kg [3]. Toxicity: CEP-18770 showed a favourable safety profile with lack of neurotoxicity and linear plasma PK. The definition of the optimal biological dose and schedule of treatment is actively pursued because of the high incidence of skin toxicity of the twice a week schedule [4].Clinical trial: CEP-18770 in Combination With Lenalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma. Phase1/2 物理化学性质： CAS号：847499-27-8 常用中文名：Delanzomib 常用英文名：CEP-18770 (Delanzomib) 分子式：C21H28BN3O5 分子量：413.275 密度：1.207 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃ |
达阳化工（杭州）有限公司
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- 产品名：CEP-18770 (Delanzomib)
- 价格： ￥216.9/10mg ￥133.9/5mg ￥411.9/25mg ￥657.9/50mg
- 纯度：97.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$165/10mM*1mLinDMSO