Folinic acid
更新时间：2022-02-12 10:14:52
采购访问：57次
| 常用名 | 亚叶酸 | CAS号 | 58-05-9 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate.Target: AntifolateFolinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. In 1980s, however, folinic acid was found to reactivate the dihydrofolate reductase itself even when methotrexate exists. Although the mechanism is not very clear, the polyglutamylation of methotrexate and dihydrofolate in malignant cells is considered to play an important role in the selective reactivation of dihydrofolate reductase by folinic acid in normal cells [1]. Folinic acid is generally administered along with MTX as a rescue agent to decrease MTX-induced toxicity. However, information regarding the inhibitory effect of folinic acid against cytogenetic damage caused by MTX is limited. This study was conducted to assess the cytogenetic effect of MTX and its inhibition by folinic acid (FA) using the micronucleus and chromosomal aberration assays concurrently [2]. 物理化学性质： CAS号：58-05-9 常用中文名：亚叶酸 常用英文名：Folinic acid 分子式：C20H23N7O7 分子量：473.43900 密度：1.68g/cm3 沸点：N/A 熔点：245ºC (decomp) 闪点：N/A 储存条件：2-8℃ |
达阳化工（杭州）有限公司
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商品数：50181件
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地址：浙江省杭州市西湖区文三路259号2栋9楼
地区： 浙江省 杭州市 西湖区
联系人：王小姐
联系人电话：+86-571-8893-8639
邮件：enquiry@dycnchem.com
网址：http://www.dycnchem.com
主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：亚叶酸
- 价格： ￥3089.9/1g ￥1029.9/250mg ￥205.9/1ml ￥10299.9/5g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：亚叶酸
- 价格： ￥需询单/100mg ￥需询单/1g ￥需询单/250mg ￥需询单/5g
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
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参考价格：$538/100mg