JNJ 31020028
更新时间：2022-02-12 19:04:53
采购访问：28次
| 常用名 | JNJ-31020028 | CAS号 | 1094873-14-9 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.IC50 value: 8.07/8.22(human/rat pIC50) [1]Target: Y2 receptor antagonistin vitro: JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04 +/- 0.13) in functional assays [1].in vivo: JNJ-31020028 occupied Y(2) receptor binding sites (approximately 90% at 10 mg/kg) after subcutaneous administration in rats [1]. Neither systemic (0, 15, 30, and 40 mg/kg, subcutaneously [s.c.]) nor intracerebroventricular (0.0, 0.3, and 1.0 nmol/rat) administration of JNJ-31020028 affected alcohol-reinforced lever pressing or relapse to alcohol seeking behavior following stress exposure. JNJ-31020028 (15 mg/kg, s.c.) did reverse the anxiogenic effects of withdrawal from a single bolus dose of alcohol on the elevated plus-maze, confirming the anxiolytic-like properties of NPY Y2 antagonism [2]. Chronic administration of JNJ-31020028 induced a decrease in immobility time in the forced swim test in OBX while had no effect in control animals [3]. 物理化学性质： CAS号：1094873-14-9 常用中文名：JNJ-31020028 常用英文名：JNJ-31020028 分子式：C34H36FN5O2 分子量：565.680 密度：1.2±0.1 g/cm3 沸点：677.5±55.0 °C at 760 mmHg 熔点：N/A 闪点：363.5±31.5 °C 储存条件：-20℃ |
达阳化工（杭州）有限公司
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外贸占销售比例：90%
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：JNJ 31020028
- 价格： ￥861.9/5mg ￥720.9/1ml ￥4325.9/100mg ￥1278.9/10mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$137/10mM*1mLinDMSO