Embelin
更新时间：2025-11-04 14:52:43
采购访问：37次
| 常用名 | 恩贝灵； 恩贝酸 | CAS号 | 550-24-3 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide).IC50 value: 4.1 uM [1]Target: XIAPin vitro: Embelin induced activation of caspase-9 and embelin-induced apoptosis was prevented by caspase inhibitors [2]. Treatment with subtoxic doses of Embelin broadly sensitized malignant glioma cells to TRAIL-mediated apoptosis. Notably, human astrocytes were not significantly affected by the combined treatment consisting of Embelin and TRAIL. Combined treatment with Embelin and TRAIL augmented the activation of initiator caspases-8/-9 and effector caspases-3/-7, respectively [3]. in vivo: Embelin inhibited topical edema in the mouse ear, leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. Furthermore, embelin was effective at reducing inflammatory damage induced by chronic TPA exposure [4]. Embelin (10, 30 or 50mg/kg body weight) was administrated daily per oral route for 7days. Embelin significantly attenuated DSS-induced DAI scores and tissue MPO accumulation, which implied that it suppressed weight loss, diarrhea, gross bleeding, and the infiltrations of immune cells. Embelin administration also effectively and dose-dependently prevented shortening of colon length and enlargement of spleen size [5]. 物理化学性质： CAS号：550-24-3 常用中文名：恩贝灵； 恩贝酸 常用英文名：Embelin 分子式：C17H26O4 分子量：294.386 密度：1.131 沸点：431.9±45.0 °C at 760 mmHg 熔点：145-146 ºC 闪点：229.1±25.2 °C 储存条件：Store at +4°C |
达阳化工（杭州）有限公司
认证状态：已认证供应商
商品数：48306件
电话：+86571-88938639
地址：浙江省杭州市西湖区文三路259号2栋9楼
地区： 浙江省 杭州市 西湖区
联系人：王小姐
联系人电话：+86-571-8893-8639
邮件：enquiry@dycnchem.com
网址：http://www.dycnchem.com
主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 云南西力生物技术股份有限公司
- 云南省 昆明市 盘龙区
- 产品名：恩贝酸
- 价格： ￥需询单/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：郑雪平
1477035482
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：恩贝酸
- 价格： ￥1366.9/100mg ￥2344.9/250mg ￥514.9/25mg ￥144.9/5mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
2881459338
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- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：酸藤子酚
- 价格： ￥688.0/20mg
- 纯度：98.0%
- 备货期：1天
- 联系人：刘佳
3007522982
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：酸藤子酚
- 价格：
- 纯度：97.0%
- 备货期：10天
- 联系人：徐经理
351666998
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13311869306
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参考价格：￥1092/50mg