GSK2801
更新时间：2025-09-08 13:38:54
| 常用名 | GSK2801 | CAS号 | 1619994-68-1 |
|---|---|---|---|
| 价格 | ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： GSK2801 is a potent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd=136 nM) and BAZ2B(Kd=257 nM) bromodomains.IC50 value: 136 nM/257 nM(Kd, BAZ2A/BAZ2B) [1]Target: BAZ2A/2B inhibitorGSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B and BAZ2A, respectively. Crystal structures demonstrated a canonical acetyl-lysine competitive binding mode. Cellular activity was demonstrated using fluorescent recovery after photobleaching (FRAP) monitoring displacement of GFP-BAZ2A from acetylated chromatin. A pharmacokinetic study in mice showed that GSK2801 had reasonable in vivo exposure after oral dosing, with modest clearance and reasonable plasma stability. Thus, GSK2801 represents a versatile tool compound for cellular and in vivo studies to understand the role of BAZ2 bromodomains in chromatin biology. 物理化学性质： CAS号：1619994-68-1 常用中文名：GSK2801 常用英文名：GSK 2801 分子式：C20H21NO4S 分子量：371.450 密度：1.2±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃ |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：GSK2801
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：GSK 2801
- 价格： ￥2544.9/100mg ￥497.9/10mg ￥994.9/25mg ￥1590.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$88/10mM*1mLinDMSO