| 常用名 | HA15 | CAS号 | 1609402-14-3 |
|---|---|---|---|
| 价格 | ¥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 exhibits strong efficacy in melanoma cells. The 50% inhibitory concentration (IC50) in A375 cells was between 1 and 2.5 mM HA15. [1]In vivo: HA15 induces ER stress leading to cancer cell death. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cellseither sensitive or resistant to BRAF inhibitors. [1] 物理化学性质: CAS号:1609402-14-3 常用中文名:HA15 常用英文名:HA-15 分子式:C23H22N4O3S2 分子量:466.576 密度:1.4±0.1 g/cm3 沸点:N/A 熔点:N/A 闪点:N/A 储存条件:-20℃ |