| 常用名 | Ponesimod | CAS号 | 854107-55-4 |
|---|---|---|---|
| 价格 | ¥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator.IC50 value: Target: S1P1 agonistin vitro: Ponesimod activated S1P(1)-mediated signal transduction with high potency (EC(50) of 5.7 nM) and selectivity [1]. in vivo: Oral administration of ponesimod to rats led to a dose-dependent decrease of blood lymphocyte count. After discontinuation of dosing, blood lymphocyte count returned to baseline within 48 h. Ponesimod prevented edema formation, inflammatory cell accumulation, and cytokine release in the skin of mice with delayed-type hypersensitivity [1]. 物理化学性质: CAS号:854107-55-4 常用中文名:Ponesimod 常用英文名:Ponesimod 分子式:C23H25ClN2O4S 分子量:460.974 密度:1.3±0.1 g/cm3 沸点:658.0±65.0 °C at 760 mmHg 熔点:N/A 闪点:351.7±34.3 °C 储存条件:-20℃ |