常用名 | Photoswitchable PAD inhibitor | CAS号 | 2226393-62-8 |
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价格 | $需询单/100mg $需询单/250mg $需询单/500mg | 纯度 | 98.0% |
备货期 | 3天 | 库存 | 3 |
产品网页 | https://www.dcchemicals.com/product_show-Photoswitchable_PAD_inhibitor.html |
产品详情(用途,包装等)
Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination. |