| 常用名 | CL2A-SN-38 | CAS号 | 1279680-68-0 |
|---|---|---|---|
| 价格 | $990.0/100mg $1700.0/250mg $220.0/10ml | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 3 |
| 产品网页 | https://www.dcchemicals.com/product_show-CL2A-SN-38.html | ||
| 产品详情(用途,包装等)
CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. |