PNU282987
更新时间：2026-05-27 08:56:56
| 常用名 | PNU-282987 | CAS号 | 123464-89-1 |
|---|---|---|---|
| 价格 | $350.0/100mg $700.0/250mg $1400.0/1g | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 3 |
| 产品网页 | https://www.dcchemicals.com/product_show-PNU282987.html | ||
| 产品详情（用途，包装等）
用途： PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).IC50 value: 26 nM(Ki) [1]Target: α7 nAChR agonistin vitro: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion [3].in vivo: Mice were subjected to 70% partial hepatic I/R for 60 min and pretreated with either vehicle or with PNU-282987, and blood and hepatic tissue samples were collected at 3, 6, and 12 h following reperfusion. pretreatment with PNU-282987 decreased serum transaminase levels and ameliorated liver injury after hepatic I/R. Moreover, pretreatment with PNU-282987 suppressed NF-κB activation, cytokine production (tumor necrosis factor α, interleukin 1β), and HMGB1 expression in liver after hepatic I/R [2]. Mice treated with 2.5 and 10 mg/kg of PNU devoted less time to rearing into open arms. In the HB task, MC mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE and SE, whereas EE displayed low exploration levels reflected in total HD (5 min) [4]. 物理化学性质： CAS号：123464-89-1 常用中文名：PNU-282987 常用英文名：PNU 282987 分子式：C14H18Cl2N2O 分子量：301.21 密度：1.3±0.1 g/cm3 沸点：431.5±30.0 °C at 760 mmHg 熔点：N/A 闪点：214.8±24.6 °C 储存条件：2-8℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：PNU 282987
- 价格： ￥113.9/10mg ￥1177.9/250mg ￥396.9/50mg ￥需询单/1g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：PNU-282987盐酸盐
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$87/10mM*1mLinDMSO