| 常用名 | 千层纸素A | CAS号 | 480-11-5 |
|---|---|---|---|
| 价格 | ¥需询单/20mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情(用途,包装等)
用途: Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1]. 物理化学性质: CAS号:480-11-5 常用中文名:千层纸素A 常用英文名:oroxylin A 分子式:C16H12O5 分子量:284.263 密度:1.4±0.1 g/cm3 沸点:540.9±50.0 °C at 760 mmHg 熔点:195-197ºC 闪点:207.4±23.6 °C 储存条件:2-8°C |