| 常用名 | 奥沙拉嗪钠 | CAS号 | 6054-98-4 |
|---|---|---|---|
| 价格 | ¥需询单/1kg ¥需询单/100g ¥需询单/100kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情(用途,包装等)
用途: Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.Target: AntibacterialOlsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Olsalazine is potent inhibitors of human intestinal macrophages chemotaxis to LTB4 with IC50 of 0.39 mM. Olsalazine (0.4 mM) inhibits the superoxide radical production generated by phorbol myristate acetate (PMA)-activated neutrophils or by xanthine-xanthine oxidase reaction by reduction of 31% and 73%, respectively. Olsalazine inhibits tumor growth in a rodent model of colorectal cancer. In 1,2-dimethylhydrazine-treated rats, Olsalazine (25 mg/kg/day) decreases number and volume of tumors by 58.17% and 62.67%, respectively. Administration of Olsalazine induces a 1.7-fold times increase in the number of apoptotic cells, companied with a reduction of 42.4% in cell proliferation rate. 物理化学性质: CAS号:6054-98-4 常用中文名:奥沙拉嗪钠 常用英文名:Olsalazine (Disodium) 分子式:C14H8N2Na2O6 分子量:346.203 密度:N/A 沸点:557.9ºC at 760 mmHg 熔点:240ºC 闪点:291.2ºC 储存条件:-20°C Freezer |