匹莫苯丹
更新时间：2025-09-02 22:43:50
| 常用名 | 匹莫苯丹 | CAS号 | 74150-27-9 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/100g ￥需询单/100mg | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.Target: PDE3Pimobendan exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM). In human atrial cells, 100 μM pimobendan significantly increases the L-type calcium current (ICa(L)) (evoked by depolarization to +10 mV from a holding potential of -40 mV) by 250.4% with the half-maximal stimulation (EC50) of 1.13 μM. In rabbit atrial cells, Pimobendan increases ICa(L) at +10 mV by 67.4.%, which is significantly lower than that obtained in human atrial cells Pimobendan shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. Administration of Pimobendan significantly increases the final survival rate from 33.6% (control) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). Pimobendan (1 mg/kg) also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. Pimobendan suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production. 物理化学性质： CAS号：74150-27-9 常用中文名：匹莫苯丹 常用英文名：Pimobendan 分子式：C19H18N4O2 分子量：334.372 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：249 °C(dec.) 闪点：N/A 储存条件：0-10°C;存放于惰性气体之中;避免空气,加热 |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Pimobendan
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Pimobendan
- 价格： ￥30.9/10mg ￥29.9/5mg ￥1144.9/1ml ￥92.9/50mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Pimobendan
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$179/10mM*1mLinDMSO