格列齐特
更新时间：2024-02-24 17:15:28
| 常用名 | 格列齐特 | CAS号 | 21187-98-4 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/100g ￥需询单/100kg ￥需询单/1ton | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.Target: Potassium Channelgliclazide further characterize its mechanism of hypoglycemic effect: the observed improvements in insulin sensitivity and in GLUT4 translocation indicate that gliclazide counters the hydrogen peroxide-induced insulin resistance in 3T3L1 adipocytes and also would further augment the hypoglycemic effect of this drug as insulinotropic sulfonylurea [1]. Gliclazide blocked whole-cell beta-cell KATP currents with an IC50 of 184 +/- 30 nmol/l (n = 6-10) but was much less effective in cardiac and smooth muscle (IC50s of 19.5 +/- 5.4 micromol/l (n = 6-12) and 37.9 +/- 1.0 micromol/l (n = 5-10), respectively). In all three tissues, the action of the drug on whole-cell KATP currents was rapidly reversible. In inside-out patches on beta-cells, gliclazide (1 micromol/l) produced a maximum of 66 +/- 13 % inhibition (n = 5), compared with more than 98 % block in the whole-cell configuration. Gliclazide is a high-potency sulphonylurea which shows specificity for the pancreatic beta-cell KATP channel over heart and smooth muscle. In this respect, it differs from glibenclamide [2]. 物理化学性质： CAS号：21187-98-4 常用中文名：格列齐特 常用英文名：Gliclazide 分子式：C15H21N3O3S 分子量：323.410 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：163-169 °C(lit.) 闪点：N/A 储存条件：-20°C Freezer |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：格列齐特
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：格列齐特
- 价格： ￥198.0/20mg ￥248.0/1g ￥178.0/5g ￥568.0/25g
- 纯度：98.0%
- 备货期：1天
- 联系人：刘佳
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：Gliclazide
- 价格： ￥589.0/1g ￥489.0/1g ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：格列齐特
- 价格： ￥151.9/5g ￥525.9/1ml ￥1370.9/100g ￥32.9/1g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$91/10mM*1mLinDMSO