雷米普利
更新时间：2024-11-10 17:31:33
| 常用名 | 雷米普利 | CAS号 | 87333-19-5 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/100g ￥需询单/100kg ￥需询单/1ton | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.Target: ACERamipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM [1]. Ramipril enhances the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells, but is unable to activate JNK or stimulate the nuclear accumulation of c-Jun in endothelial cells expressing a S1270A ACE mutant or in ACE-deficient cells. Prolonged Ramipril treatment increases ACE expression in primary cultures of human endothelial cells and in vivo (mouse lung), which can be prevented by pretreatment with the JNK inhibitor SP600125 [2].Chronic in vivo administration of Ramipril to rats at a dosage that has similar hypotensive effects in vitro HUVECs significantly reduces the rate of LPS-induced apoptosis compared to the other ACE inhibitors, which contrasts with the apoptosis effect in vitro [3]. Ramipril inhibits systolic blood pressure (SBP) with IC50 of 1.97 mg/kg in spontaneously hypertensive rats (SHR). When in combination with AT1-receptor blockade by candesartan-cilexetil increases SBP reduction synergistically rather than additively [4]. 物理化学性质： CAS号：87333-19-5 常用中文名：雷米普利 常用英文名：Ramipril 分子式：C23H32N2O5 分子量：416.511 密度：1.2±0.1 g/cm3 沸点：616.2±55.0 °C at 760 mmHg 熔点：106-108°C 闪点：326.4±31.5 °C 储存条件：2-8°C |
- 江西瑞威尔生物科技有限公司
- 江西省 吉安市 峡江县
- 产品名：雷米普利
- 价格： ￥800.0/50g ￥需询单/100mg ￥需询单/10g ￥需询单/100g
- 纯度：98.0%
- 备货期：1天
- 联系人：李经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：雷米普利
- 价格： ￥30.9/100mg ￥33.9/500mg ￥179.9/5g ￥289.9/1ml
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$66/10mM*1mLinDMSO