Clevidipine
更新时间：2024-09-20 09:51:00
| 常用名 | 丁酸氯维地平 | CAS号 | 167221-71-8 |
|---|---|---|---|
| 价格 | $需询单/1mg | 纯度 | 96.406% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.IC50 Value: 7.1 nM at V(H) = -40 mV [1]Target: calcium channelin vitro: Both clevidipine and nitroglycerin completely reversed U46619-induced contraction (clevidipine (50% effective concentration [EC50] = 3.88 +/- 0.84 x 10(-6) mol/L, nitroglycerin EC50 = 4.84 +/- 2.76 x 10(-8) mol/L) [2]. A decrease in temperature increased the half-life of clevidipine in blood, whereas dilution of the blood did not affect the in vitro half-life of clevidipine. The albumin concentration affected the hydrolysis rate of clevidipine in RBC suspended with saline [3].in vivo: Clevidipine is a high-clearance drug with a relatively small volume of distribution, resulting in an extremely short half-life in all species studied. The median initial half-life of the individual value (Bayesian estimates) is 12, 20, and 22 s in the rabbit, rat, and dog, respectively [4]. The extremely high clearance value and the small volume of distribution resulted in short half-lives of clevidipine, 2.2 and 16.8 min, respectively. The blood concentration and dose rate producing half the maximal effect (i.e. EC50 and ED50) were approximately 25 nM and 1.5 microg/kg/min, respectively [5].Clinical trial: CARVE: Clevidipine for Vasoreactivity Evaluation of the Pulmonary Arterial Bed. Phase 4 物理化学性质： CAS号：167221-71-8 常用中文名：丁酸氯维地平 常用英文名：Clevidipine 分子式：C21H23Cl2NO6 分子量：456.316 密度：1.3±0.1 g/cm3 沸点：539.7±50.0 °C at 760 mmHg 熔点：128-130°C 闪点：280.2±30.1 °C 储存条件：Refrigerator |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Cleviprex
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：丁酸氯维地平
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/250mg
- 纯度：97.0%
- 备货期：需询单
- 联系人：王汐瑶
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：氯维地平
- 价格： ￥147.9/100mg ￥54.9/25mg ￥485.9/1ml ￥970.9/1g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$66/10mM*1mLinDMSO