3-苯基磺酰基-8-(哌嗪-1-基)喹啉
更新时间：2025-07-29 15:50:01
| 常用名 | 英特匹定 | CAS号 | 607742-69-8 |
|---|---|---|---|
| 价格 | ￥需询单/1kg | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.IC50 Value: 9.63 (pKi)Target: 5-HT6 ReceptorSB-742457, a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. SB-742457 is generally safe and well tolerated and may be efficacious in Alzheimer disease. 物理化学性质： CAS号：607742-69-8 常用中文名：英特匹定 常用英文名：SB742457 分子式：C19H19N3O2S 分子量：353.438 密度：1.3±0.1 g/cm3 沸点：608.3±45.0 °C at 760 mmHg 熔点：N/A 闪点：321.7±28.7 °C 储存条件：-20℃ |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Intepirdine (SB-742457, RVT-101）
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：SB742457
- 价格： ￥292.9/1mg ￥2572.9/25mg ￥968.9/5mg ￥1017.9/1ml
- 纯度：97.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$158/10mM*1mLinDMSO