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Mianserin hydrochloride

更新时间:2025-08-26 16:03:20

常用名 盐酸米安色林 CAS号 21535-47-7
价格 ¥需询单/1g 纯度 98.0%
备货期 1天 库存 现货
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 产品详情(用途,包装等)
用途:
Mianserin hydrochloride is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.Target: H1 receptorMianserin is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects. It is not approved for use in the US, but its analogue, mirtazapine, is. Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose.Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, and α2-adrenergic receptors, and also inhibits the reuptake of norepinephrine. As a high affinity H1 receptor inverse agonist, mianserin has strong antihistamine effects (sedation, weight gain, etc.). Contrarily, it has negligible affinity for the mACh receptors, and thus lacks any anticholinergic properties. It was recently found to be a potent kappa opioid receptor agonist. In addition, mianserin also appears to be a potent antagonist of the neuronal octopamine receptor. What implications this may have on mood are currently unknown, however octopamine has been implicated in the regulation of sleep, appetite and insulin production and therefore may theoretically contribute to the overall side effect profile of mianserin.
物理化学性质:
CAS号:21535-47-7
常用中文名:盐酸米安色林
常用英文名:Mianserin hydrochloride
分子式:C18H21ClN2
分子量:300.826
密度:1.18 g/cm3
沸点:411.3ºC at 760 mmHg
熔点:>230ºC (dec.)
闪点:186.1ºC
储存条件:库房通风低温干燥

供应商信息

上海芮晖化工科技有限公司

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