SKF-86002
更新时间：2025-08-27 20:29:08
| 常用名 | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 | CAS号 | 72873-74-6 |
|---|---|---|---|
| 价格 | ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).IC50 value:Target: p38 MAPK inhibitorin vitro: SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 [2]. SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP [3]. 物理化学性质： CAS号：72873-74-6 常用中文名：6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 常用英文名：SKF 86002 分子式：C16H12FN3S 分子量：297.350 密度：1.4±0.1 g/cm3 沸点：476.1±55.0 °C at 760 mmHg 熔点：189-190ºC(lit.) 闪点：241.7±31.5 °C 储存条件：2-8℃ |
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：SKF 86002
- 价格： ￥1036.0/5mg ￥需询单/1g ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑
- 价格： ￥1496.0/10mg ￥3276.0/25mg ￥446.0/1mg ￥5966.0/50mg
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
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6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑生产厂家
参考价格：$165/10mM*1mLinDMSO