盐酸格拉司琼
更新时间：2024-09-16 17:05:53
| 常用名 | 盐酸格拉司琼 | CAS号 | 107007-99-8 |
|---|---|---|---|
| 价格 | ￥需询单/1kg | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Granisetron Hcl(BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) [1]Target: 5-HT3 receptorin vitro: In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT [1].in vivo: Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion [2]. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation [3].Clinical trial: Effect of External Heat on a Transdermal Granisetron Patch in Pharmacokinetics (PK) of Healthy Subjects. Phase 1 物理化学性质： CAS号：107007-99-8 常用中文名：盐酸格拉司琼 常用英文名：Granisetron hydrochloride 分子式：C18H25ClN4O 分子量：348.870 密度：1.33g/cm3 沸点：532ºC at 760mmHg 熔点：290-292°C 闪点：275.6ºC 储存条件：Room temp |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：盐酸格拉司琼
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：盐酸格拉司琼
- 价格： ￥708.0/10mg ￥2108.0/50mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Granisetron HCl
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：盐酸格拉司琼
- 价格： ￥31.9/10mg ￥344.9/1g ￥144.9/250mg ￥124.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$92/10mM*1mLinDMSO