Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo [2, 3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based …

NGM Davies, H Browne, B Davis, MJ Drysdale…

文献索引：Bioorganic and Medicinal Chemistry, , vol. 20, # 22 p. 6770 - 6789

被引用次数: 13

摘要

... Bioorganic & Medicinal Chemistry. ... Some compounds in this chemical series inhibit the proliferation of human cancer cell lines in vitro and cause depletion of oncogenic Hsp90 client proteins and concomitant elevation of the co-chaperone Hsp70. ...

52133-67-2

2-氰基-4,4-二乙氧基丁酸乙酯

67831-83-8

2-甲硫基-4-羟基-7H-吡...

Targeting conserved water molecules: design of 4-aryl-5-cyan...

[Davies, Nicholas G.M.; Browne, Helen; Davis, Ben; Drysdale, Martin J.; Foloppe, Nicolas; Geoffrey, Stephanie; Gibbons, Ben; Hart, Terance; Hubbard, Roderick; Jensen, Michael Rugaard; Mansell, Howard; Massey, Andrew; Matassova, Natalia; Moore, Jonathan D.; Murray, James; Pratt, Robert; Ray, Stuart; Robertson, Alan; Roughley, Stephen D.; Schoepfer, Joseph; Scriven, Kirsten; Simmonite, Heather; Stokes, Stephen; Surgenor, Allan; Webb, Paul; Wood, Mike; Wright, Lisa; Brough, Paul Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 22 p. 6770 - 6789]