Synthesis and antiviral evaluation of carbocyclic analogs of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines

…, JD Clayton, G Arnett, WM Shannon

文献索引：Shealy; Clayton; Arnett; Shannon Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 670 - 674

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被引用次数: 14

摘要

Carbocyclic analogues of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino- 6-substituted-8-azapurines were prepared from the 2-amino-6-chloropurine ribofuranoside analogue (2) and the 2-amino-6-chloro-8-azapurine ribofuranoside analogue (9), respectively. Analogues of purine ribofuranosides with the chloro, amino, methylamino, or methylthio group at position 6, the thioguanosine analogue, and the previously reported ...