Tetrahedron letters

Palladium-phosphinous acid-catalyzed cross-coupling of aliphatic and aromatic acyl chlorides with boronic acids

K Ekoue-Kovi, H Xu, C Wolf

文献索引：Ekoue-Kovi, Kekeli; Xu, Hanhui; Wolf, Christian Tetrahedron Letters, 2008 , vol. 49, # 40 p. 5773 - 5776

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被引用次数: 30

摘要

The cross-coupling of aromatic and aliphatic acyl chlorides with arylboronic acids in the presence of 2.5 mol% of (t-Bu2POH) 2PdCl2 (POPd) provides rapid access to ketones that are obtained in up to 93% yield. This palladium-phosphinous acid-catalyzed reaction is completed within 10min when microwave irradiation is used, and it overcomes typical drawbacks of Friedel–Crafts acylation procedures such as harsh reaction conditions, ...