Novel synthetic 2-amino-10-(3, 5-dimethoxy) benzyl-9 (10H)-acridinone derivatives as potent DNA-binding antiproliferative agents

C Gao, F Liu, X Luan, C Tan, H Liu, Y Xie, Y Jin…

文献索引：Gao, Chunmei; Liu, Feng; Luan, Xudong; Tan, Chunyan; Liu, Hongxia; Xie, Yonghua; Jin, Yibao; Jiang, Yuyang Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7507 - 7514

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被引用次数: 26

摘要

A series of novel 9 (10H)-acridinone derivatives with terminal amino substituents at C2 position on the acridinone ring were synthesized and studied for their antiproliferative activity and underlying mechanisms. These compounds demonstrated promising cytotoxicity to leukemia cells CCRF-CEM, displaying IC50 values in the low micromolar range. Structure– activity relationships (SAR) indicated that the compound 6d bearing a pyrrolidine ...